Publications

Research Output

I have published over 20 peer-reviewed articles with >300 citations, focusing on computational methods for multi-omics data analysis, biomarker discovery and drug development. My current work spans from developing novel computational tools to identifying clinically relevant biomarkers in gynecological cancers. In my PhD I worked on evaluating drug candidates and developing new screening methods for neglected tropical diseases, using computational methods and PK/PD models for cocrystals, prodrugs and novel formulations.

All Publications

Data source: cached BibTeX file

2025

Standardization of Suspension and Imaging Mass Cytometry Single-Cell Readouts for Clinical Decision Making

R Casanova, S Xu, P Bost, S Sivapatham, A Jacobs, … S Engler

Cytometry Part A (2025)

Research Output

All Publications

2025

Standardization of Suspension and Imaging Mass Cytometry Single-Cell Readouts for Clinical Decision Making

Integrating Formalin-Fixed, Paraffin-Embedded-Derived Whole-Genome Sequencing into Routine Molecular Pathology: Validation and First Experiences in Metastatic Melanoma

Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming

Binary classification of gynecological cancers based on ATR-FTIR spectroscopy and machine learning using urine samples

Tumor-Associated Macrophages Improve The Efficacy Of SMAC Mimetics Combined With Chemotherapy In Ovarian Cancer

2024

Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

2023

174 Integrated multi-omic and clinicopathological analysis of vulvar squamous cell carcinoma: identification of predictive biomarkers for personalized treatment

2022

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

2022-RA-1446-ESGO Comprehensive assessment of gene mutations revealed overlapping dependencies for PARPi and chemotherapy response in ovarian cancer

1P Comprehensive assessment of gene mutations revealed overlapping responses for PARPi and chemotherapy in ovarian cancer cells

2020

Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs

Evaluation of Human Liver Microtissues for Drug Screening on Schistosoma mansoni Schistosomula

Antischistosomal Drugs: Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs (Adv. Biosys. 7/2020)

Development of novel strategies to fill the empty drug pipeline for schistosomiasis: from drug sensitivity assay development to preclinical studies

2019

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni

Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model

Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment

2018

Impedance-based microfluidic assay for automated antischistosomal drug screening

Microfluidic impedance Platform for long-term detection of parasite viability

Combining mechanochemistry and spray congealing towards new praziquantel formulations

Impedance analysis of viability of Schistosoma mansoni larvae for drug screening applications

Microfluidic platform for parallelized and automated viability detection of Schistosoma mansoni

2017

Impedance-based detection of Schistosoma mansoni larvae viability for drug screening

Microfluidic impedance platform for automated schistosomal motility detection

Software & Tools

Published Packages