Publications

Research Output

I have published several peer-reviewed articles with >200 citations, focusing on computational methods for multi-omics data analysis, biomarker discovery, and drug development. My current work spans from developing novel computational tools to identifying clinically relevant biomarkers in gynecological cancers. In my PhD I worked on developing new drugs against neglected tropical diseases, using computational methods and PK/PD models, especially for cocrystals and prodrugs.

You can find the updated publication list here: 🎓 Google Scholar

All Publications from Google Scholar

2025

Tumor-Associated Macrophages Improve The Efficacy Of SMAC Mimetics Combined With Chemotherapy In Ovarian Cancer

Ricardo Coelho, Brinton Seashore-Ludlow, Sarah Schütz, Flavio Christopher Lombardo, Valentine Schmid, Lina Alflen, Tibor Andrea Zwimpfer, Michal Hensler, Andre Fedier, Jitka Fucikova, others
International Journal of Gynecological Cancer, 35 (2025)

Binary classification of gynecological cancers based on ATR-FTIR spectroscopy and machine learning using urine samples

Francesco Vigo, Alessandra Tozzi, Flavio C Lombardo, Muriel Eugster, Vasileios Kavvadias, Rahel Brogle, Julia Rigert, Viola Heinzelmann-Schwarz, Tilemachos Kavvadias
Clinical and Experimental Medicine, 25, 1–11 (2025)

2024

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

Ricardo Coelho, Brinton Seashore-Ludlow, Sarah Schütz, Flavio Christopher Lombardo, Elisabeth Moussaud-Lamodière, Ruben Casanova, Joanna Ficek-Pascual, Kathrin Brunhilde Labrosse, Michal Hensler, Monica Lopez-Nunez, others
bioRxiv, 2024–01 (2024)

Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models

Kathrin B Labrosse, Flavio C Lombardo, Natalie Rimmer, Mónica Núñez López, André Fedier, Viola Heinzelmann-Schwarz, Ricardo Coelho, Francis Jacob
STAR protocols, 5, 103274 (2024)

2022

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

Cecile Cumin, Yen-Lin Huang, Charlotte Rossdam, Felix Ruoff, Susana Posada Cespedes, Ching-Yeu Liang, Flavio C Lombardo, Ricardo Coelho, Natalie Rimmer, Martina Konantz, others
Cell Reports, 40 (2022)

Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer

Ricardo Coelho, Alessandra Tozzi, Muriel Disler, Flavio Lombardo, André Fedier, Mónica Núñez López, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz
Cell Death & Disease, 13, 909 (2022)

1P Comprehensive assessment of gene mutations revealed overlapping responses for PARPi and chemotherapy in ovarian cancer cells

A Tozzi, R Coelho, M Disler, F Lombardo, A Fedier, M Nunez Lopez, F Freuler, F Jacob, V Heinzelmann-Schwarz
Annals of Oncology, 33, S383 (2022)

2020

Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs

Paolo S Ravaynia, Flavio C Lombardo, Stefan Biendl, Matthias A Dupuch, Jennifer Keiser, Andreas Hierlemann, Mario M Modena
Advanced biosystems, 4, 1900304 (2020)

Antischistosomal Drugs: Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs (Adv. Biosys. 7/2020)

Paolo S Ravaynia, Flavio C Lombardo, Stefan Biendl, Matthias A Dupuch, Jennifer Keiser, Andreas Hierlemann, Mario M Modena
Advanced Biosystems, 4, 2070073 (2020)

Evaluation of human liver microtissues for drug screening on Schistosoma mansoni Schistosomula

Flavio C Lombardo, Paolo S Ravaynia, Mario M Modena, Andreas Hierlemann, Jennifer Keiser
ACS infectious diseases, 7, 1894–1900 (2020)

Development of novel strategies to fill the empty drug pipeline for schistosomiasis: from drug sensitivity assay development to preclinical studies

Flavio Christopher Lombardo
(2020)

2019

Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model

Flavio C Lombardo, Beatrice Perissutti, Jennifer Keiser
European Journal of Pharmaceutics and Biopharmaceutics, 142, 240–246 (2019)

Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment

Beatrice Albertini, Beatrice Perissutti, Serena Bertoni, Debora Zanolla, Erica Franceschinis, Dario Voinovich, Flavio Lombardo, Jennifer Keiser, Nadia Passerini
International journal of molecular sciences, 20, 1233 (2019)

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni

Flavio C Lombardo, Valérian Pasche, Gordana Panic, Yvette Endriss, Jennifer Keiser
Nature Protocols, 14, 461–481 (2019)

2018

Combining mechanochemistry and spray congealing towards new praziquantel formulations

B Albertini, B Perissutti, S Bertoni, ZANOLLA Debora, E Franceschinis, D VOINOVICH, F LOMBARDO, J PASSERINI, others
(2018)

Impedance-based microfluidic assay for automated antischistosomal drug screening

Ketki Chawla, Mario M Modena, Paolo S Ravaynia, Flavio C Lombardo, Martin Leonhardt, Gordana Panic, Sebastian C Bürgel, Jennifer Keiser, Andreas Hierlemann
ACS sensors, 3, 2613–2620 (2018)

Software & Tools

Published Packages

  • drugsens - CRAN package for drug sensitivity analysis
Metrics
  • h-index: 7
  • Total citations: 260
  • i10-index: 7

View my complete publication list on Google Scholar | ResearchGate