Research Output
I have published over 20 peer-reviewed articles with >300 citations, focusing on computational methods for multi-omics data analysis, biomarker discovery and drug development. My current work spans from developing novel computational tools to identifying clinically relevant biomarkers in gynecological cancers. In my PhD I worked on evaluating drug candidates and developing new screening methods for neglected tropical diseases, using computational methods and PK/PD models for cocrystals, prodrugs and novel formulations.
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All Publications
2026
Ex vivo drug sensitivity testing predicts treatment outcomes in advanced ovarian cancer
KB Labrosse, FC Lombardo , EM Bartoszek, L Sauteur, N Tanner, … T Tanna
npj Precision Oncology (2026)
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2025
Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming
U Lischetti, CY Liang, M Carrara, R Coelho, A Hanns, … F Lombardo
Nature communications (2025)
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Standardization of Suspension and Imaging Mass Cytometry Single-Cell Readouts for Clinical Decision Making
R Casanova, S Xu, P Bost, S Sivapatham, A Jacobs, … S Engler
Cytometry Part A (2025)
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Integrating Formalin-Fixed, Paraffin-Embedded-Derived Whole-Genome Sequencing into Routine Molecular Pathology: Validation and First Experiences in Metastatic Melanoma
C Litchfield, R Nienhold, A Wicki, M Schmid, … D Aguilera-Garcia
The Journal of Molecular Diagnostics (2025)
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Binary classification of gynecological cancers based on atr-ftir spectroscopy and machine learning using urine samples
F Vigo, A Tozzi, FC Lombardo , M Eugster, V Kavvadias, R Brogle, … J Rigert
Clinical and Experimental Medicine (2025)
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Tumor-Associated Macrophages Improve The Efficacy Of SMAC Mimetics Combined With Chemotherapy In Ovarian Cancer
R Coelho, B Seashore-Ludlow, S Sch”utz, FC Lombardo , … V Schmid
International Journal of Gynecological Cancer (2025)
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2024
Protocol for quantifying drug sensitivity in 3D patient-derived ovarian cancer models
KB Labrosse, FC Lombardo , N Rimmer, MN L’opez, … A Fedier
STAR protocols (2024)
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SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis
R Coelho, B Seashore-Ludlow, S Sch”utz, … F Christopher Lombardo
bioRxiv (2024)
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2023
# 174 Integrated multi-omic and clinicopathological analysis of vulvar squamous cell carcinoma: identification of predictive biomarkers for personalized treatment
TA Zwimpfer, F Lombardo , N Rimmer, S G”otze, F Singer, … A Bertolini
International Journal of Gynecological Cancer (2023)
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2022
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
C Cumin, YL Huang, C Rossdam, F Ruoff, SP Cespedes, … CY Liang
Cell Reports (2022)
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Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer
R Coelho, A Tozzi, M Disler, F Lombardo , A Fedier, MN L’opez, … F Freuler
Cell Death & Disease (2022)
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2022-RA-1446-ESGO Comprehensive assessment of gene mutations revealed overlapping dependencies for PARPi and chemotherapy response in ovarian cancer
A Tozzi, M Disler, R Coelho, F Lombardo , A Fedier, MN Lopez, … F Freuler
International Journal of Gynecological Cancer (2022)
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1P Comprehensive assessment of gene mutations revealed overlapping responses for PARPi and chemotherapy in ovarian cancer cells
A Tozzi, R Coelho, M Disler, F Lombardo , A Fedier, MN Lopez, … F Freuler
Annals of Oncology (2022)
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2020
Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs
PS Ravaynia, FC Lombardo , S Biendl, MA Dupuch, … J Keiser
Advanced biosystems (2020)
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Evaluation of Human Liver Microtissues for Drug Screening on Schistosoma mansoni Schistosomula
FC Lombardo , PS Ravaynia, MM Modena, A Hierlemann, J Keiser
ACS infectious diseases (2020)
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Antischistosomal Drugs: Parallelized Impedance-Based Platform for Continuous Dose-Response Characterization of Antischistosomal Drugs (Adv. Biosys. 7/2020)
PS Ravaynia, FC Lombardo , S Biendl, MA Dupuch, … J Keiser
Advanced Biosystems (2020)
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Development of Novel Strategies to Fill the Empty Drug Pipeline for Schistosomiasis: From Drug Sensitivity Assay Development to Preclinical Studies
F Lombardo
Philosophisch-Naturwissenschaftliche Fakult”at der Universit”at Basel (2020)
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2019
Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni
FC Lombardo , V Pasche, G Panic, Y Endriss, J Keiser
Nature Protocols (2019)
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Activity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model
FC Lombardo , B Perissutti, J Keiser
European Journal of Pharmaceutics and Biopharmaceutics (2019)
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Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment
B Albertini, B Perissutti, S Bertoni, D Zanolla, … E Franceschinis
International journal of molecular sciences (2019)
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2018
Impedance-based microfluidic assay for automated antischistosomal drug screening
K Chawla, MM Modena, PS Ravaynia, FC Lombardo , … M Leonhardt
ACS sensors (2018)
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Microfluidic impedance platform for long-term detection of parasite viability
PS Ravaynia, K Chawla, MM Modena, F Lombardo , … J Keiser
(2018)
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Combining mechanochemistry and spray congealing towards new praziquantel formulations
B Albertini, B Perissutti, S Bertoni, D Zanolla, … E Franceschinis
Hungarian Society of Pharmaceutical Sciences (2018)
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Impedance analysis of viability of Schistosoma mansoni larvae for drug screening applications
MM Modena, K Chawla, F Lombardo , SC B”urgel, G Panic, … J Keiser
(2018)
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Microfluidic platform for parallelized and automated viability detection of Schistosoma mansoni
K Chawla, MM Modena, PS Ravaynia, F Lombardo , G Panic, … S B”urgel
SELECT Bio Lab-on-a-chip and microfluidics Europe conference (2018)
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2017
Impedance-based detection of Schistosoma mansoni larvae viability for drug screening
MM Modena, K Chawla, F Lombardo , SC B”urgel, G Panic, … J Keiser
(2017)
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Microfluidic impedance platform for automated schistosomal motility detection
K Chawla, M Leonhardt, MM Modena, F Lombardo , … SC B”urgel
(2017)
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